C Diff Treatment – Your step by step guide

Here is a detailed overview of c diff treatment – from the mildest case to the most severe.

Stop taking the antibiotics

If your case is mild – diarrhea 3-5 times a day you will probably find that the symptoms stop after you finish the course of antibiotics you have been taking.

Get tested to clarify what strain you have

If your symptoms continue you may need to get tested. There are many different strains of c.difficile. The NAP1 or 027 strain is often caught in hospital and is much more destructive than other strains. A test will help ensure the right antibiotic treatment for your strain.

C Diff Treatment – Flaygl

The common and least expensive drug used is Flagyl (metronidazole). This is effective against mild to moderate strains. For many people this c diff treatment works and it goes away after 7-14 days. About 20% of the patients are not cured and more powerful drugs must be used. Find out more at our detailed Flagyl page

C Diff Treatment – Vancocin

This is the oral form of the common vancomycin drug used for many other conditions. It takes the medication directly to the infected area and is effective for many patients. It is more expensive and is also usually reserved for the worst cases, so that strains vulnerable to one of the drugs of ‘last resort’ do not develop. There is a concern that it subdues c.difficile rather than killing it. Recent research is also suggesting that it is a short term cure and makes the gut more liable to more c difficile and other infections. Find out more at our Vancocin page. Some hospitals use a Flaygl/Vancocin combination to treat c.difficile.

Dificid – Fidaxomicin

This a a newer drug that targets a specific aspect of the c.difficile bacteria. It does less damage to the rest of the stomach flora and those treated with it are less likely to have further infections. It is very expensive. Find out more at our Fidaxomicin page

C Diff Treatment – Fecal transplants (FMT)

The treatment of last resort is a fecal microbiota transplant. This new therapy involves placing specially treated fecal matter from a relative or carefully chosen donor inside the intestine of a sufferer is also being used. The evidence so far indicates that for many it ends their chronic C Diff infections. Find out more about fecal transplants here .


See other C Diff Treatment pages below

Recent C Diff Treatment News

53 thoughts on “C Diff Treatment – Your step by step guide

  1. Alita MacElhiney

    Help! I have been on antibiotics for most of a year for diverticulitis. Had bowel resection surgery in August. Recovery time went well. However, have had three bouts of c diff. All with vanco 125MG and now with 250MB. One of the treatments involved pulsed administration… 10 days, 5, days, 2 days etc. The bout now is extremely painful, diarrhea constantly and extreme fatigue.

    I am afraid that the new vanco will not work. Is there any reason why the oral version would not work but the IV version would? Since the development of c diff, I have a low tolerance for oral medications. I know that vanco is not absorbed but what do I do. I am at my wits end. It is now affecting both my work and home life. I feel dirty… :-(

    Reply
    1. Infection Watch

      Some doctors are using a Flagyl/Vanco combination and other are using Dificid which is linked to less recuurence as it actually kills C Diff rather than supressing it. You may want to discuss this with your doctor.

      Dave

      Reply
  2. Michael McCann

    Dave’s reply to Kristi is good advice. If symptoms clear permanently after Vancomycin no further treatment is needed. However if lingering symptoms persist, then a good quality probiotic can be curative. There are several good preparations on the market and those containing these three species work best; 1) L acidophilus, 2) L bulgaricus, 3) Bifofobacteria bifidum. The main problem in using probiotics either for prevention or therapy is that the doses used are much to small and not long enough. Because the C diff occupies the same niche as these three commensurates (and No 2 is a transient whereas 1 and 3 can permanently colonize and prevent living space for the C diff) then treatment should be initiated with large doses and then decreased to maintenance doses until stools test negative for C diff.

    Reply
  3. Kristi Brooks

    I was diagnosed for C diff after antibiotic use (Clindamycin) following a minor surgery. I was slowing getting sick but thought it was a stomach virus. As it got worse, I went to the hospital and was there for 3 days. I was sent home with 11 day supply of Vancomycin (on it in the hospital too) I am feeling better, not 100% but close. Wondering when am I cured from C diff? My bowels are not normal yet, but getting there. How do I know I am done??

    Reply
    1. Infection Watch

      You are best to ask an MD or those who treated you but the return of normal firm stools is probably the best measure of the end of your infection.

      Dave
      cdifficile.org

      Reply
  4. Michael McCann

    This is a very important question because we know that antibiotic use is a main cause of C diff overgrowth, but what we do not know is whether the probiotic used will also be killed off by the antibiotic used. In the future I hope all probiotics will be accompanied by specific antibiotic sensitivity testing on their labels. Then we can select resistant probiotics to use along with the therapeutic antibiotic. Right now it is anybody’s guess because the studies have not been done.

    Reply

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