Vancocin & C Difficile – 4 Key Facts For You

Vancocin is a trade name for vancomycin, a drug of last resort for many conditions including c. difficile and MRSA.

When is Vancocin prescribed?

In c. difficile cases it is often given after Flagyl has failed. It will usually be given to people suffering moderate to severe cases of infection.

How does Vancocin work?

It works by interfering with the bacteria cell wall mechanism and thereby halting it’s reproduction. It is given via mouth rather than the normal intravenous method used for other conditions. This help deliver the drug straight to the target area in the intestine rather than needing to disperse it via the bloodstream.

It is has a major new competitor – Fidaxomicin – which kills the c diff bacteria rather than just suppressing it. Vancomycin is considerably cheaper however. There are concerns that vancocin stops the c difficile in the short term but leaves the patient more vulnerable to future attacks because of the negative impact of the drug on other key positive gut bacteria. This relates to c difficile and other infections.

What dosage is used?

The suggested dose is 125 mg, administered orally, 4 times daily for 10 days. There is a study on whether a Flaygl/Vancocin combination delivers a better outcome for the patient with less long term weakness in the gut bacteria. Other treatment approaches include the combination of a fecal transplant (FMT) with vancocin – this is an interesting approach as many believe that the  FMT is enough to cure 90 – 97% of sufferers.

What about side effects?

While there are concerns about the long term impact of vancocin on the gut bacteria, other side effects in other parts of the body are rare except in relation to prolonged courses of treatment.  You can find out more about these at the vancomycin page at Wikipedia and this page at Drugs.com. Wikipedia notes that these include:

Local pain, which may be severe, and thrombophlebitis.  Later trials using purer forms of vancomycin found nephrotoxicity is an infrequent adverse effect (0.1–1% of patients), but this is accentuated in the presence of aminoglycosides.[12]

Rare adverse effects (<0.1% of patients) include: anaphylaxis, toxic epidermal necrolysis, erythema multiforme, red man syndrome, superinfection, thrombocytopenia, neutropenia, leukopenia, tinnitus, and dizziness and/or ototoxicity


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19 thoughts on “Vancocin & C Difficile – 4 Key Facts For You

  1. Marjorie Okie I can't believe I can ever be well again.

    I took 2 14 day 4 pills daily Flagyl and now 2 14 day Vancomycin and continued always with the c difficile since July. Now I am told I will need a fecal transplant probably. And will it come back?

    1. Jan Murray

      I also went through 14 days on Flagyl, then 10 days on Rifaxamin, then 10 days on 250 mg. Vancomycin 4x daily (around the clock). I still had C. Diff. I went to see an Infectious Disease Specialist (see my earlier comment above) and am now on Vancomycin 3x daily (none at night) until all SYMPTOMS are gone and stools look normal for me; then I’m to be on Vanco 3 days a week, stop for four days a week, and repeat that pattern for 6-8 weeks. Only then, if C. Diff is not gone, will I need fecal transplant. See an Infectious Disease Specialist for recurring C. Diff!!!
      Jan

  2. Jan Murray

    I have had C. Diff since July and have been treated with Flagyl for 14 days, got what I believe was a false negative, was then on Xifaxan 550 mg for 10 days, and now Vancomycin 250 mg for 10 days. I got the severe form of this infection from taking Clindamycin prescribed by my dentist. Xifaxan made me feel better than the other two meds, but I tested positive for C. Diff at the end of that course of treatment and believe I still have it as I still have diarrhea near the end of the Vancomycin course, which — not incidentally — cost just pennies under $1,600 because I’m in the Medicare gap. I know of Dificid. I have an appt. with an Infectious Disease Specialist next week and expect she will prescribe Dificid. Do you know of any way to get samples or reduction of the cost which is more than $3,300 according to online information!
    Thank you for your help!

    1. Pattie W

      I worked in biotech for the last 6 years. I suggest you get on the website of the manufacturer of that drug and see if they will give a discount or clinical trial you can enroll in or if the distributer can discount the price.

      1. Jan Murray

        Thank you! Through an Infectious Disease Specialist, Shelley Gordon, PhD, MD, in SF, I found out the oral liquid is $75 for 10 days vs. $1600 for the pills, and she was also able to get a Medicare pre-authorization for a year. Yay!
        Jan

  3. Maggie

    I had an abcess tooth and took cynclimycin 9SP0 and amoxicillin. I have taken flagly 250 mg for 10 days.It came back I took 500mg of flagyl for 10 more days ..it came back. I then had to pay $400.00 for the vancomycin for yet another 10 days and it’s back. I am in dispair..what next?

    1. admin Post author

      Dificid is widely touted as being better at halting c diff. You might like to enquire about that.

      Dave
      cdifficile.org

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