Vancocin is a trade name for vancomycin, a drug of last resort for many conditions including c. difficile and MRSA.
When is Vancocin prescribed?
In c. difficile cases it is often given after Flagyl has failed. It will usually be given to people suffering moderate to severe cases of infection.
How does Vancocin work?
It works by interfering with the bacteria cell wall mechanism and thereby halting it’s reproduction. It is given via mouth rather than the normal intravenous method used for other conditions. This help deliver the drug straight to the target area in the intestine rather than needing to disperse it via the bloodstream.
It is has a major new competitor – Fidaxomicin – which kills the c diff bacteria rather than just suppressing it. Vancomycin is considerably cheaper however. There are concerns that vancocin stops the c difficile in the short term but leaves the patient more vulnerable to future attacks because of the negative impact of the drug on other key positive gut bacteria. This relates to c difficile and other infections.
What dosage is used?
The suggested dose is 125 mg, administered orally, 4 times daily for 10 days. There is a study on whether a Flaygl/Vancocin combination delivers a better outcome for the patient with less long term weakness in the gut bacteria. Other treatment approaches include the combination of a fecal transplant (FMT) with vancocin – this is an interesting approach as many believe that the FMT is enough to cure 90 – 97% of sufferers.
What about side effects?
While there are concerns about the long term impact of vancocin on the gut bacteria, other side effects in other parts of the body are rare except in relation to prolonged courses of treatment. You can find out more about these at the vancomycin page at Wikipedia and this page at Drugs.com. Wikipedia notes that these include:
Local pain, which may be severe, and thrombophlebitis. Later trials using purer forms of vancomycin found nephrotoxicity is an infrequent adverse effect (0.1–1% of patients), but this is accentuated in the presence of aminoglycosides.
Rare adverse effects (<0.1% of patients) include: anaphylaxis, toxic epidermal necrolysis, erythema multiforme, red man syndrome, superinfection, thrombocytopenia, neutropenia, leukopenia, tinnitus, and dizziness and/or ototoxicity
More C Difficile Treatment Information
- Fidaxomicin (Dificid) & C Difficile – 6 key facts you should know
- Flagyl (Metronidazole) & C Difficile Treatment
- Vancocin & C Difficile – 4 Key Facts For You
- C Diff Fecal Transplant Therapy – 7 Key Facts
- Why do some people have recurrent C Diff infections?
Recent Vancocin News
- Disease progression and resolution in rodent models of Clostridium difficile infection and impact of antitoxin antibodies and vancomycin. - PubMed - NCBI
- New antibiotics in clinical trials for Clostridium difficile. - PubMed - NCBI
- Oral Vancomycin Prophylaxis Effective for Prevention of Recurrent C. Diff Infection
- A pilot study to assess bacterial and toxin reduction in patients with Clostridium difficile infection given fidaxomicin or vancomycin. - PubMed - NCBI
- Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of Clostridium difficile Infection
- Vancomycin treatment alters humoral immunity and intestinal microbiota in an aged mouse model of Clostridium difficile infection. - PubMed - NCBI