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C Diff Fecal Transplant Therapy – 7 Key Facts

C diff fecal transplant therapy is sometimes known as Fecal Microbiota Transplant (FMT). Because some people suffer chronic c difficile doctors are using a new therapy to dislodge the disruptive c diff from their intestine. Fecal matter from a family member is often sought so that the material entering their system is reflective of local stomach flora. This is then turned into a liquid slurry and inserted into the body to colonise the intestine.

How do fecal matter transplants work?

For most people this introduces a new balance in the intestine and restores the bacteria depleted by antibiotic treatment. This bacteria would in normal circumstances combat the c diff anyway. It is by no means clear as yet exactly how the cure takes place in specific biological terms – but the general theory that recolonizing the colon with healthy bacteria will reverse the c difficile seems to be true. Some research indicates that the reintroduction of Bacteroidetes and Firmicutes elements are part of the cure.

What is a Fecal Microbiota Transplant?

The c diff fecal transplant is inserted into the intestine in one of 4 ways. Via a duodenal tube, a rectal tube, a colonoscopy or possibly via special fecal tablets enclosed in a shell which dissolves in in the intestine . The colonoscopy is favoured as the whole of the colon can be recolonized and the extent of the infection can be clarified during the process. The cure may happen within hours or a few days.

Has the procedure been validated?

This is a not a new therapy, but it has been a rare one until the recent mushrooming of c difficile infections. It has been tested via clinical trials  and we link to information about those below. One of the major trials was extended to include those not receiving the therapy as it was felt to be unethical not to help them recover.

The FDA in the USA did seek to regulate the process and surround every procedure with extensive paperwork. They stepped back from this amidst a hail of protest from front-line doctors who were seeing sick people get well within days.

In late 2015 the BMJ carried an article from those supportive of the FMT treatment that nevertheless called for oversite of the procedure to help prevent cross infection of the patient with a condition new to them: They said:

“We have very rigorous screening protocols for donors to maximize safety. We check for any infections. We ask question about their weight and we won’t let them donate if they’re obese, or if they have colon cancer or polyps. If you do a fecal transplant at home, God knows who your donor is, what you’re transferring,” he said. Read More

Does c diff fecal transplant therapy work?

Success rates of 97% have been noted and those for whom it does not work are often those seeking a fecal transplant for ulcerative colitis. Overall a cure rate of 89% in 275 cases from a round the world has been noted. Initial research also suggest that a small minority who have further c diff infections have been reinfected from another source.

Who can have a stool transplant?

This process is usually a last resort treatment. It will not be the first thing offered with your first c difficile infection. You will also need to find a facility willing to do c diff fecal transplants. Use a search engine to look for ‘fecal microbiota transplant xxxxxxxx. (Insert name of your state or city instead of xxxxxx.)

Who can be a fecal transplant donor?

You will need to find a suitable donor, with family members preferred. You should note that their fecal matter will need to be tested and that much of the cost of the process – usually between $1500-2000 – relates to that testing. This is to ensure that they do not pass you another unhelpful infection. You should also note that heavily medicated people or recent users of antibiotics will not be suitable donors. A ‘fecal donor bank’ is also creating a resource for hospitals so that can can obtain pre-screened fecal matter for use in the procedure.

Is there a Fecal Transplant Pill?

Work is under way to discover the essential elements of the fecal donation that heal the c diff infection. This would then be used to create pills or highly specific targeted drugs that attack some aspect of the infection process – that could then bypass the need for the intrusive procedure. It is also believed that this type of therapy could help several other conditions and research on those continues.

Other C Difficile Treatment Pages

Recent c diff fecal therapy news

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  1. Diane Diane

    I feel for you. Tomorrow I will have a fecal transplant this after 6 months off and on c-diff problems. I just finished my 3rd round of vanocycom yesterday (250 mg. 4 x a day at a very costly price. Am so depressed don’t even feel like going anywhere just feel awful. No appetite, tired stomach pain and of course the loose bowel movements. Praying tomorrow’s procedure will help. Thinking of you and hope you feel better soon. This is not fun I know.

  2. Debra B. Welch Debra B. Welch

    I had FMT late spring, enjoyed some months of wellness, now am stricken again. We follow every precaution, had dogs tested, I’m past flagyl and halfway through the vanco course again. Can barely get out of bed, hopeless. Sorry, stuck in a pity party 🙁

  3. Mulan Mulan

    Hi. Did u have any side effects with it at home diy?

  4. There is a small failure rate. There is also some anecdital evidence of it sometimes taking several days. Let us know if it does not work out and we’ll look into the research we have


  5. carole villegas carole villegas

    I have C diff and had a fecal transplant. The dr’s all say that the transplant takes effect immediately. Define immediately? Its has been 4 days now and counting and I still am suffering. So , what do I do next? I took Flagyl to get rid of the infection and that was about 70 % effective.
    Help, any suggestions?

  6. Jean Jhanson Jean Jhanson

    My mother has Myleodysplastic Syndrome and treatment was unsuccessful. She was infected with C-Diff during one of her hospital stays. We scheduled the FMT but before we could do the procedure she was placed in Hospice Care and is weak and bedridden. I had to make a difficult decision to cancel the FMT due to our Hospice nurse felt it was risky to do and may cause her life to be shortened. I fear I made the wrong decision as the MDS can be managed but it may be the C-Diff that ends her life.

  7. Patricia Taylor Patricia Taylor

    I have cusody of my 2 years old grand-daughter and she has tested posivite three times for C.Difficile. She has been treated at Nemours in Jacksonville Florida. She has tried many compounds in which did nothing. She has stomach pains and cries for hours at a times along with pure yellow, watery bowel movements daily. The bowel movements even burn and she cries. I have been told of the transplant would she be a canidate? We live in Brunswick, Georgia and any one off us would be willing to be a donor. Please help me to help her as she is our life! I do need to tell you she does not talk, walk, stand, crawl, eat or drink. She has a G-J tube I feed her with. I have been to Emory in Atlanta, Georgis for genetic testing still waiting results. We have also been referred to The Marcus Autism Center in Atlanta but there id a 9-12 month wait to get in. I have been fighting since she was about 6 month old for help and to find out what all is going on with nothing as of yet. Any feed back will hep. Thank you

    • Lisa Hurka Covington Lisa Hurka Covington

      In response to Patricia Taylor… I am offering additional information as a c diff survivor. Please see the C diff Foundation website for more information per pediatric care. The below information is referenced on their site. Hope this will help your dear grandchild.

      Dr. Sujal Rangwalla, a pediatric gastroenterologist providing FMT, experimental treatment
      Dell Children’s Medical Center of Central Texas

    • Nancy Copeland Nancy Copeland

      FMT is a must for anyone with C-Diff. My son had one this week after almost 4 months with C-diff and the antibiotics they prescribe. It now has major inflammation through out his colon. The problem is the doctors need to perform FMT with the first diagnosis of C-diff. It is cruel, costly and negligent of the FDA ro require doctors and patience to through a ton of red tape to be able to use FMT to cure the C-diff.

  8. RJ RJ

    Attn: Lisa Hurka Covington and everyone else..

    I NEED help.. I have C-Diff and do NOT have a family member donor that will work. My husband is on too many medications.
    I’m in the near Nashville, TN area.. I’m mid 50’s, female and am so sad I don’t have a donor. I know I would help anyone I could if the situation were reversed. I’ve been fighting this for over a year after I picked it up in a hospital stay and PLEASE I need a donor that lives near me. Vanderbilt hospital is where they will do it. They said I must find my own donor that lives near me.
    PLEASE email me if you have any ideas of someone who can help or just to talk to me about this. I’m scared.

    Thanks SO much. RJ

    • Lisa Hurka Covington Lisa Hurka Covington

      Dear RJ,
      I am so sorry you are going through all you are with c diff, you will get stronger and better. I will keep you in prayers, they are powerful.

      I am enclosing information for you to go to for help with your transplant. Go to and then go in the search box and you can type in stool bank OR on the right side of the page in category Fecal transplants FMT scroll through the information about the stool back on MASS.

      If you need me for anything further, I am always here for you.

      With warm wishes,

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