Why do some people have recurring C Diff infections?


This is an area where research is ongoing, but here are some of the possible reasons.

1 They have been reinfected through another hospital contact and a cycle of sickness has started again

2 The drugs previously given subdued it but did not kill it. There is some evidence that some bacteria will ‘switch off’ and go dormant in their fight against vancocin. When the balance of the intestine is disturbed again by drug treatment for another illness the latent c diff is re-activated.

3 Little is known about the general prevelance of c difficile in the environment and community. Figures of 3-35% who might be ‘silent carriers’ are sometimes mentioned in the scientific literature. There is also a growing body of evidence that some are suffering c difficile infections without hospital contact. The possibility of community spread cannot be ruled out.

4 The intestine can sometimes be so disturbed by drug treatment, infection and illness that it struggles to get right. The controversial fecal transplant method does suggest that healthier fecal matter can restore the intestine to balance and break the cycle of illness

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{ 82 comments… read them below or add one }

Elizabeth January 8, 2015 at 1:37 am

I would like to email or Facebook my mother this article but you only offer “twitter”, “google” and “redddit”. I’m not proficient with a social media and could use some help. My mother has suffered from 4 c-diff infections since 6-4-14 while being hospitalized over 12 time following a knee surgery that started this reoccurring condition. She underwent a fecal transplant in September, 2014 but the c-diff returned when doing a miralax prep for a follow-up colonoscopy to remove a large polyp that was discovered during the fecal transplant. C-diff then reared its ugly head again this January 2015 after being hospitalized due to an abscess involving a diverticulitis pocket rupture. Thank you for you consideration to add an “email” or “facebook” option. Sincerely Elizabeth


admin January 8, 2015 at 9:19 am

I have enabled those 2 options



Rhonda Howell September 18, 2014 at 5:01 pm

My 22 year old daughter has been battling C-diff for nine months. She was hospitalized at one point for it. We have no idea why it keeps coming back, but she stays wiped out with no energy. Is there anything we can do other than the medications that she takes when it recurs to prevent this? I am very worried. She is adamantly against a fecal transplant and after seeing where it hasn’t really worked on people on here I am wondering if it is worth it to even try. Any advice you can give is appreciated.


admin September 19, 2014 at 10:28 am

Please check out our page on this at http://www.cdifficile.org/what-is-the-c-diff-fecal-transplant-therapy/ It is worth noting that the FMT proceedure works for most people most of the time. Also has she had Dificid – this medication is thought better than most at stopping future attacks of C Diff.



Debby Gallup September 19, 2014 at 1:57 pm

I suffered with C Diff for 2 years, 11 recurrences. I had all the meds for C Diff, Flagyl, Vancomycin and Dificid. It’s been a year since my fecal transplant and it has not come back!! I would not hesitate to have another one if needed, the next day I felt so much better and have been C Diff free since. Debby


Garnet Oltmann September 29, 2014 at 4:52 am

It appears you need to seek another doctor/doctors. The disease KILLS people. I almost died from it. Dificid is a great drug. I was in the hospital for 30 days and this is the only drug that took care of my problem. That was 4 years ago and I have not had a problem since then. Please go to another doctor/doctors until you find one that will take care of the problem. Your daughter is too young to have to live with this. After what I went though I would not have a problem with the fecal procedure. I am 71 years old. Not a problem for me after spending 30 days in hospital in another state. Trust me, c-diff is NOT something you want to let go on without treatment.

Good Luck.


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